猫和老鼠：迷失之龙动画全集讲述善良的巫女雅典娜收养了很多受伤的动物，其中包括汤姆和杰瑞，可是由于雅典娜巫女的身份使得她受到精灵的排挤，只能独身住在小木屋中。这时，雅典娜的阿姨，一个邪恶的巫女，想通过龙蛋获得强大的力量，从而报复将她驱逐的村民，但是阴差阳错汤姆捡到了龙蛋，故事又会如何发展呢？

Our favorite cat and mouse are back with song, sorcery and slapstick in this enchanted tale with two bonus cartoons. The adventure begins when Tom and Jerry happen upon a mysterious glowing egg. Little do they know, this egg was stolen from a very large fire breathing dragon! In short time, baby Puffy hatches from his egg and takes Tom as his mommy. The angry mama dragon wants her baby back, but she's not the only one...a powerful witch named Drizelda captures the baby dragon for her own wicked plans! With the help of powerful allies and animal friends, Tom and Jerry must fight tooth and claw to stop the witch and get the baby dragon back to its mother. The action takes flight in a climactic ending filled with might, magic, and cartoon mayhem of course!